Evol Ecol Res 8: 1445-1459 (2006) Full PDF if your library subscribes.
Ageing and total quality management: extending the reliability metaphor for longevity
David Steinsaltz1* and Lloyd Goldwasser2
1Department of Mathematics and Statistics, Queen’s University, Kingston, Ontario K7L 3N6, Canada and 2Department of Demography, University of California, Berkeley, CA 94720-2120, USA
Author to whom all correspondence should be addressed.
Question: How can the limitations and potential of biological repair processes be reconciled with evolutionary theory to understand patterns of ageing?
Approach: Current mathematical models of ageing under conditions of biological repair are drawn from a limited range of engineering analogies that implicitly assume repair is perfect and/or harmless, with the only constraint being its cost to a common energy budget. Other analogies suggest new models which may be (and in some cases are being) fruitfully developed. A useful guiding principle is the engineer’s ‘total quality management’, which imposes a balance between high-level and low-level design.
Key point: Reparability itself may impose trade-offs against, for instance, reliability and efficiency, and may not always be advantageous, even when cost-free.
Conclusions: Because the repair of damage is often incomplete or imperfect, the accumulation of repair increases the disorder within the system over time, decreasing the effectiveness of the local controls over repair. Asymmetry and sequestration appear to be ways of channelling the disorder to parts of the systems that are reparable.
Keywords: ageing, damage segregation, evolutionary models of senescence, optimization, reliability models.
DOWNLOAD A FREE, FULL PDF COPY
IF you are connected using the IP of a subscribing institution (library, laboratory, etc.)
or through its VPN.
© 2006 David Steinsaltz. All EER articles are copyrighted by their authors. All authors endorse, permit and license Evolutionary Ecology Ltd. to grant its subscribing institutions/libraries the copying privileges specified below without additional consideration or payment to them or to Evolutionary Ecology, Ltd. These endorsements, in writing, are on file in the office of Evolutionary Ecology, Ltd. Consult authors for permission to use any portion of their work in derivative works, compilations or to distribute their work in any commercial manner.
Subscribing institutions/libraries may grant individuals the privilege of making a single copy of an EER article for non-commercial educational or non-commercial research purposes. Subscribing institutions/libraries may also use articles for non-commercial educational purposes by making any number of copies for course packs or course reserve collections. Subscribing institutions/libraries may also loan single copies of articles to non-commercial libraries for educational purposes.
All copies of abstracts and articles must preserve their copyright notice without modification.